Home Healthcare Products Intranasal Light Therapy Helmet

Basic Concepts In Photobiomodulation

Photobiomodulation involves the use of light within the visible red (600-700 nm) or near infrared (NIR) (700 nm-1400 m) range that is produced from a laser or light-emitting diode (LED) source. These wavelengths coincide with the “optical window” of mammalian skin, that is, the wavelength at which there is maximal absorption of light. Unlike regular lasers which produce tissue heating or ablation, absorption of light by a chromophore in PBM produces a photochemical effect that is analogous to photosynthesis in plants. Cytochrome C oxidase, a member of the mitochondrial electron transport chain, acts as the chromophore that leads to production of adenosine triphosphate (ATP), generation of reactive oxygen species, and induction of cell signaling.This results in cell proliferation, down-regulation of inflammation, increased tissue oxygenation, wound healing, nerveregeneration, and pain reduction.

Principle:

Cytochrome C oxidase (CCO, also known as complex IV) is a specific structure in mitochondria that ACTS as a photon receptor and thus plays the PBM effect.PBM prevents respiratory inhibition (and correspondingly reduces energy storage) in stress cells by isolating nitric oxide (NO) and reversing the shift of oxygen in cytochrome C oxidase.This triggers transcription factors that alter gene expression levels.The binding of nitric oxide (NO) to copper (or heme) centers in the mitochondrial cytochrome C oxidase (CCO) inhibits cell respiration.But cytochrome C oxidase, which absorbs red or near-infrared (NIR) light, dissociates nitric oxide, restoring oxygen, increasing cellular respiration, and forming adenosine triphosphate (ATP).This triggers a cascade of intracellular reactions involving nitric oxide, reactive oxygen species (ROS), and cyclic adenosine phosphate (cAMP) that produce beneficial effects of PBM. 

Main Functions:

• Open heat-gated ion channels and modulate the transcription factors

• Improves cytochrome c oxidase function in mitochondria

• Enhance neuroprotective proteins and growth factors

• Increases active oxygen content inside the brain

• Promotes cerebral ATP energy production

• Accelerate intracranial blood flow

Main Indications

Traumatic events (stroke, traumatic brain injury, and global ischemia).

Degenerative diseases (dementia, Alzheimer’s and Parkinson’s).

Mental disorders (depression, anxiety, post traumatic stress disorder).

Experiment We Do

One of the experiments cooperate with the Complementary and Integrative Laser Medicine, Biomedical Engineering in Anesthesia and Intensive Care Medicine, Medical University.
Showed a clear response of cerebral rSO2 in relation to the our PBM helmet stimulation. 
December, 2018

One of the experiments cooperate with the German Healthcare field organization

Showed a clear response of NADH reduction, which means the increasing of ATP in relation to our PBM helmet stimulation.

May, 2019

One of the experiments conducted by Italy brain health organization
29 Italian patients underwent NIR stimulation therapy for 1-month, tested before and after and shown good results 

March, 2020

Product Usage

Take out the helmet,power adapter, control box, fixation sponges, connection cables from the handbag. Stick the sponges inside helmet.

1.  Connect the helmet, power adapter, control box. Pic.①

2.  Put the helmet on the head and sit on a comfortable place. Pic.②

3.  Connect the power. Pic.③

4.  Adjust the suitable power, frequency and time, then press Run/Stop button to start treatment. Pic.④

    (Note: When the power is adjusted to 100%, the near-infrared light is a continuous wave with full power,so there is no frequency and no flicker)

5.  After the time is over, put off the helmet, then disconnect the power.Pic.⑤

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Company Introduction

Many reports and datas, if you want more details, welcome to contact me.